Effect of ethidium bromide and fractionated x-irradiation on Rauscher leukemia development. [Mice]

Journal Article · Tue Jan 01 04:00:00 EST 1974 · Int. J. Cancer; (United States)

DOI:https://doi.org/10.1002/ijc.2910140508· OSTI ID:7325787

OKunewick, J P; Brozovich, B J; Kuhnert, P M

Studies were carried out to evaluate further the in vivo effectiveness of reverse-transcriptase inhibitors in the therapy of Rauscher viral leukemia. Ethidium bromide, given in multiple doses, was found to be without significant effect on the survival of mice which already had established Rauscher disease as the result of injection with virus 2 weeks earlier. However, the initiation of ethidium bromide treatment immediatly after virus did result in the beneficial effect of an increase in the mean survival time of the infected animals. On the other hand, at the virus titers used, 4-N-benzyl-4-N-demethylrifampicin showed no significant therapeutic action in either case, even though other studies had suggested that it might be effective for this purpose. A total of 1,000 R of fractionated x-irradiation given to animals with established leukemia also resulted in increased mean survival times, but the combination of irradiation and ethidium bromide treatment of similar mice resulted in only a marginal improvement over irradiation alone. It is suggested that these reverse-transcriptase inhibitors, though active against the free virus, may not be effective against the already transformed tumor cell.

• Research Organization: Allegheny General Hospital, Pittsburgh
• OSTI ID: 7325787
• Journal Information: Int. J. Cancer; (United States), Journal Name: Int. J. Cancer; (United States) Vol. 14; ISSN IJCNA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BROMIDES
BROMINE COMPOUNDS
DISEASES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
HALIDES
HALOGEN COMPOUNDS
HEMIC DISEASES
IONIZING RADIATIONS
IRRADIATION
LEUKEMIA
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
PARASITES
RADIATION EFFECTS
RADIATIONS
RODENTS
SURVIVAL TIME
THERAPY
VERTEBRATES
VIRUSES
X RADIATION