Rauscher leukemia as a model for cancer therapy studies. I. Response to acute and fractionated irradiation

Journal Article · Mon Sep 01 04:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575350· OSTI ID:6880292

Seeman, P R; Okunewick, J P; Brozovich, B

The response of Rauscher leukemia to various radiotherapy protocols was tested to determine its possible suitability as a model for therapy. Similar to human leukemia, Rauscher leukemia responded positively to both acute and fractionated radiation exposures with remission of symptoms and prolongation of survival times. Also similar to radiotherapy of human leukemia, a high incidence of relapse following the remissions was noted. Single acute exposures to x irradiation were less effective against the disease than fractionated exposures, and large fractionated exposures given at relapse were less effective than multiple smaller fractions given immediately upon detection of clinical leukemia symptoms. Comparison of the response of normal control mice to the same protocols used on the leukemic mice revealed that repeated exposures to 400 to 550 R given at the time when the leukemic mice relapsed resulted in an accumulation of residual radiation injury, leading to death of the control as well as the leukemic mice. In contrast, a total of 1000 R given in 10 fixed exposure doses early in the disease gave a similar protection to that found with five 400-R exposures (2000 R total) given at relapse and yielded a much lower incidence of radiation lethality in the normal controls. Other characteristics of Rauscher leukemia comparing it to human disease as well as the results of various clinical groups on the utilization of radiotherapy for leukemia are treated in the discussion.

• Research Organization: Allegheny General Hospital, Pittsburgh, PA
• OSTI ID: 6880292
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
BIOLOGICAL MODELS
BLOOD COUNT
COMPARATIVE EVALUATIONS
DATA
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
HEMIC DISEASES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
LEUKEMIA
MAMMALS
MEDICINE
MICE
MORTALITY
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RODENTS
SIDE EFFECTS
SURVIVAL CURVES
SURVIVAL TIME
SYMPTOMS
THERAPY
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION