Rauscher leukemia as a model for cancer therapy studies. II. Variation in response of splenic CFU-S between normal and Rauscher leukemic mice following exposure to hydroxyurea

Journal Article · Tue Jan 01 04:00:00 EST 1980 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-163-40734· OSTI ID:5263784

Okunewick, J P; Meredith, R F; Brozovich, B J; Seeman, P R

Normal mice and mice with advanced Rauscher leukemia were given a single dose of HU and evaluated for the effect of the drug on splenic CFU-S 4 and 16 hr later. Exposure to HU reduced the total number of CFU-S for both normal and leukemic mice by 50% at 4 hr. At 16 hr there was no recovery in CFU-S evident in the normal mouse. However, CFU-S levels in the spleens of the leukemic mice had recovered to nearly that existent before exposure to HU. Effects of HU on total splenic mass differed from that on the CFU-S. Recovery of total splenic mass was seen to have begun in normal animals by 16 hr after HU, while in the leukemic animals spleen size had receded further by 16 hr. The data suggest that, as in man, the hematopoietic recovery responses following exposure to chemotherapeutic drugs may be significantly different in Rauscher viral leukemic mice as compared to normal mice. The possible applicability of Rauscher leukemia as a model for leukemia therapy studies is briefly discussed.

• Research Organization: Clinical Radiation Therapy Research Center, Pittsburgh, PA
• OSTI ID: 5263784
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 163:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AMIDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BODY
CFU
CHEMOTHERAPY
COLONY FORMATION
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DISEASES
EXPERIMENTAL DATA
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HYDROGEN ISOTOPES
HYDROXY COMPOUNDS
HYDROXYUREA
INFORMATION
ISOLATED VALUES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKEMIA
LEUKEMIA VIRUSES
LIGHT NUCLEI
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARASITES
RADIOISOTOPES
RECOVERY
RESPONSE MODIFYING FACTORS
RODENTS
SENSITIVITY
SIDE EFFECTS
SPLEEN
SPLEEN COLONY FORMATION
THERAPY
TIME DEPENDENCE
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
VIRUSES
YEARS LIVING RADIOISOTOPES