Therapeutic effect of exogenous DNA as function of dosage given to irradiated mice. [Gamma radiation]

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:7316467

Kim, V Kh; Ivannik, B P; Ryabchenko, N I

Noninbred mice, 3 to 4 months old, were exposed to single doses of 650, 730, and 900 R of /sup 60/Co gamma quanta. The animals received subcutaneous injections of DNA isolated from chick erythrocytes 24 hours after irradiation. After a radiation dose of 730 R, administration of DNA (7.5 mg/kg) resulted in raising survival rate to 33.6%, as opposed to 3.6% in the control. The survival rate of controls constituted 25.6% after a dosage of 650 R; it was 50.6% in animals given DNA (7.5 mg/kg). After exposure to a dose of 900 R, administration of DNA extended mean survival to 9.4 days, as compared to 5.4 days in the control.

• Research Organization: Inst. of Medical Radiology, Obninsk, USSR
• OSTI ID: 7316467
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:1; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DNA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IONIZING RADIATIONS
MAMMALS
MICE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL CURVES
THERAPY
VERTEBRATES