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PROPHYLACTIC AND THERAPEUTIC EFFECTS OF THE SYNERGISTIC ACTION OF EFFECTIVE SUBSTANCES ON RADIATION SICKNESS IN ANIMALS (in Russian)

Journal Article · · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR
OSTI ID:4683365
;
Effects of various combinations of cystamine, purine, and pyrimidine compounds, pyridoxin (vitamin B/sub 6/), and narcotic drugs on radiation sickness in animals were studied for 30 days in white mice (male) weighing 18 to 20 g. The animals were subjected to x irradiation with 700 r from a PYM-11 apparatus at 41.4 r/min. The highest protective effect was obtained by an intraperitoneal injection of 150 mg/kg cystamine 30 min before exposure followed by a subcutaneous injection of 50 mg/kg antifein immediately after exposure (58% survival rate). An injection of 150 mg/kg cystamine 30 min before exposure followed by an injection of 50 mg/kg antifein immediately after exposure and intraperitoneal injections of vitamin B (1 mg/kg) for seven consecutive days after exposure resulted in a 60% survival rate. The narcotic drug barbamyl (100 mg/kg) inhibited the effect of antifein (20% survival rate), whereas chloral hydrate (also a narcotic drug), injected in a dose of 300 mg/kg immediately after exposure, increased the protective effect of antifein (100 mg/kg), resulting in a 58% survival rate. The data obtained indicate that the effectiveness of the preparations used depends on their chemical nature, dose, time, and sequence of administration. Activation and inactivation of the protective substances may occur simultaneously in the animal organism. (auth)
Research Organization:
Originating Research Org. not identified
NSA Number:
NSA-17-033761
OSTI ID:
4683365
Journal Information:
Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 8: No. 5; ISSN MERAA
Country of Publication:
Country unknown/Code not available
Language:
Russian

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Related Subjects

AMINES
ANESTHESIA
ANTIFEIN
BARBITURIC ACID
BIOLOGY AND MEDICINE
CYSTAMINE
DRUGS
HETEROCYCLICS
MICE
ORGANIC NITROGEN COMPOUNDS
PREPARATION
PURINES
PYRIMIDINES
RADIATION PROTECTION
RADIATION SICKNESS
SURVIVAL TIME
VITAMIN B-6
VITAMINS
X RADIATION