ON THE MECHANISM OF CYSTAMINE (2-AMINOETHYLDISULFIDE) RADIATION PROTECTION

Journal Article · Mon Dec 31 23:00:00 EST 1962 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4016280

Graevskii, E Ya; Konstantinova, M M; Nekrasova, I V; Tarasenko, A G

The relations between the protective effects of cystamine, the oxygen content in tissues, and inhaled oxygen were studied in 8- to 12-week-old white mice weighing 18 to 20 g, Mice were injected with cystamine 15 min before exposure to 700 to 900 r of y rays at 236 r/min. It was found that 5 mg of cystamine injected either intravenously or intraperitoneal prevented lethality after 900 r. Cystamine penetrates Erlich ascites cancer cells in approximately the same quantity in vivo and in vitro. However, its protective effects are active only in vivo. It was considered that the protective qualities of cystamine are the products of its transformation in the organism into cysteamine. (R.V.J.)

• Research Organization: Severtsov Inst. of Animal Morphology, Moscow
• NSA Number: NSA-18-019800
• OSTI ID: 4016280
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AGE
AMINES
ANIMAL CELLS
BIOLOGY AND MEDICINE
CHEMICAL REACTIONS
CYSTAMINE
EFFICIENCY
EHRLICH ASCITES
ETHYL RADICALS
GAMMA RADIATION
IRRADIATION
LETHAL DOSE
LUNGS
MEA
METABOLISM
MICE
ORGANIC SULFUR COMPOUNDS
OXYGEN
PHYSIOLOGY
RADIATION DOSES
RADIATION PROTECTION
RADIOBIOLOGY
TESTING
TISSUES
TUMORS