PROTECTIVE EFFECTS OF CYSTEAMINE AND CYSTAMINE ON THYMOCYTES IRRADIATED "IN VITRO" (in French)
Journal Article
·
· Rev. Franc. Etudes Clin. Biol.
OSTI ID:4659366
Both cysteamine and its oxidation product cystamine are to some extent toxic for a suspension of rat thymus cells. The toxicity varies with the suspension medium, being less in serum than in Krebs solution. The diminished toxicity in serum probably results from protein fixation of cysteamine and cystamine. Cysteamine and cystamine protect the thymus cells against some effects of irradiation. Pyknosis and pyknolysis is inhibited in thymus cells irradiated in vitro. Although cysteamine causes a fall in oxygen concentration in the medium, this drop is not observed with cystamine, and the protective effect of the latter cannot be produced by an oxygen effect. (auth)
- Research Organization:
- Universite, Liege
- NSA Number:
- NSA-17-033764
- OSTI ID:
- 4659366
- Journal Information:
- Rev. Franc. Etudes Clin. Biol., Journal Name: Rev. Franc. Etudes Clin. Biol. Vol. Vol: 6
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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