ACTION OF CYSTEAMINE AND CYSTAMINE ON METABOLISM IN THE LIVER AND KIDNEY OF MALE RATS POISONED WITH SODIUM FLUOROACETATE (in French)
Hepatic and renal levels of citrate were followed in rats poisoned with fluoroacetate and injected intraperitoneally with the radioprotective agents cysteamine (10 mg/100 g) or cystamine 112 mg/100 g). Hepatic citrate level was also followed in rats irradiated with 800 to 850 r and injected with cysteamine before or after irradiation. The accumulation of citrate in kidney induced by fluoroacetate was diminished by pretreatment with cysteamine, but its effect on the kidney may be caused by the circularory changes it produces. Cystamine was similarly effective in reducing renal citrare. Cysteamine, but not cystamine, increased liver citrate levels, thus appeared to aggravate the action of the poison on liver cells. Cystamine, but not cysteamine, diminished hepatic citrate when given before or after irradiation and injection of fluoroacetate. Cystamine, but not cysteamine, augmented the ability of rats to acetylate sulfanilamide. The results show that these 2 compounds may have quite different effects. They may protect agalnst fluoroacetate poisoning by modifying the distribution of coenzyme A or indirectly by altering hormone secretion, since citrate accumulation is influenced by castration and adrenalectomy. (H.R.D.)
- Research Organization:
- Universite, Liege
- NSA Number:
- NSA-17-001260
- OSTI ID:
- 4767096
- Journal Information:
- Arch. Intern. Physiol. Biochim., Journal Name: Arch. Intern. Physiol. Biochim. Vol. Vol: 69
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
Similar Records
Hepatic cysteamine and non-protein sulfhydryl levels following cystamine or cysteamine treatment of galactosamine-poisoned rats
PROTECTION AGAINST IRRADIATION AFFORDED BY SODIUM FLUOROACETATE
Related Subjects
ADRENAL GLANDS
AMINO ACIDS
ANIMAL CELLS
BIOLOGY AND MEDICINE
BLOOD CIRCULATION
CITRIC ACID
CYSTAMINE
CYSTEAMINE
DISTRIBUTION
ENZYMES
GONADS
HORMONES
KIDNEYS
LIVER
METABOLISM
ORGANIC SULFUR COMPOUNDS
QUANTITY RATIO
RADIATION DOSES
RADIATION PROTECTION
RATS
SEX
SODIUM COMPOUNDS
SULFONAMIDES
SURGERY
TOXICITY