PROTECTION AGAINST IRRADIATION AFFORDED BY SODIUM FLUOROACETATE
Sodium fluoroacetate injected into mice at a dose of 4 to 5 mg/kg, 5 hours before irradiation, reduced the mortality produced by 650 to 675 r of whole- body x irradiation. The high levels of citric acid in the tissues of the poisoned animals returned to normal within 24 hours if 675 r of x rays were given 5 hours after 5 mg/kg of sodium fluoroacetate, whereas 48 hours was required in the case of nonirradiated control mice. Thus, x rays interfered with the metsbolism of citric acid in the tissues of the mouse as in the tissues of the rat. The liver of the mouse, however, did not behave like the liver of the rat. In contrast to rats, male mice injected with sodium fluoroacetate accumulated citrate in their livers, whereas females did not; whole-body irradiation reduced the level of accumulated citrate in the liver as it did in other tissues of the mouse. The injection of sodium fluoroacetate produced a prolonged hypothermia. It is suggested that the flouroacetate-induced becumulation of citrate protects the animals by complexing magnesium ions necessary for DNase activity. (auth)
- Research Organization:
- Universite, Liege
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-021336
- OSTI ID:
- 4166910
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 13
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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