INFLUENCE OF CYSTEAMINE ON THE RENAL CITRIC ACID LEVEL IN THE MALE RAT IRRADIATED AND POISONED WITH SODIUM FLUOROACETATE (in French)
S>In rats poisoned with fluoroacetate, injection of radioprotective doses (12 mg/100 g) of cysteamine 15 min later depressed the accumulation of citrate in kidney caused by this poison. However, if given 12 hr later the effect of the poison is not modified. Irradiation of the rats with 800 r diminished the rise in renal citrate caused by fluoroacetate, and this effect of irradiation is accentuated by injection of cysteamine 3 min before or 15 min after irradiation. Renal citrate level of rats poisoned 24 hr after irradiation was lower than in nonirradiated rats and cysteamine enhanced this effect of irradiation. The action of cysteamine on renal citrate was not evident before 48 hr after irradiation when it was injected before or after irradiation. Cysteamine was radioprotective only if injected 3 min before irradiation and when there was a 72-hr delay between irradiation and fluoroacetate treatment. (H.H.D.)
- Research Organization:
- Universite, Liege
- NSA Number:
- NSA-17-001261
- OSTI ID:
- 4773709
- Journal Information:
- Arch. Intern. Physiol. Biochem., Journal Name: Arch. Intern. Physiol. Biochem. Vol. Vol: 69
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
Similar Records
PROTECTION AGAINST IRRADIATION AFFORDED BY SODIUM FLUOROACETATE
EFFECT OF FLUOROACETATE AND X RAYS ON THE CITRIC ACID CONTENT IN THE LIVER OF MICE