LOCAL AND GENERAL CHEMICAL PROTECTION AGAINST EPILATION BY X IRRADIATION

Journal Article · Sat Dec 31 23:00:00 EST 1960 · Bull. Acad. Roy. Med. Belg.

OSTI ID:4746440

Bacq, Z M; Beaumariage, M -L; Radivojevitch, D V

Changes in skin and hair growth were investigated in C57 mice exposed to 200- to 700-r doses of whole-body x radiation at the age of 5 to 8 days. It was noted that hair follicles were more resistant in the younger mice; the threshold epilating dose was approximates 400 r in 5-day-old mice compared with 300 r in 8- day-old mice. The 700-r dose consistently and completely inhibited hair growth at the age of 5 days, accelerated epilation at the age of 8 days, and retarded regeneration. After 700 r, approximates 1 month was required for hair regrowth, and after 300-400 r, approximates 3 weeks. Cysteamine (250 to 750 mu g), cysteine, and MEG (mercaptoethylguanidine) gave local protection while cystamine (250 to 750 mu g) gave generalized protection against epilation. Histamine, injected in sufficiently high dosage (1.1 mg) in skin or peritoneum, afforded complete protection of hair follicles, and weaker doses (11 mu g) of histamine or of a histamine liberator (Compound 48/80, 1.5 mu g) gave local protection when injected in skin. Subcutaneously administered tryptamine (156 mu g) or 5- hydroxytryptamine (8.5 to 1150 mu g) gave generalized protection against epilation, and small doses (31 to 62 mu g) of tryptamine gave local protection. Antihistamine agents (Phenergan, Neoartergan, Antistine), when injected in 10- mu g doses in skin or 90- mu g in peritoneum 30 min before administration of radioprotectants: consistently abolished the local and general protection conferred by histamine; diminished in half the mice tested the local protection afforded by low doses of cysteamine; and did not inhibit the general protection given by cystamine. Bol-148, an antagonist of 5hydroxytryptamine, when injected 30 min before 5-hydroxytryptamine or tryptamine, inhibited the local and general protection given by the latter amines. Among the other agents tested for anti- epilatory action against x irradiation, significant protection was afforded by diethydithiocarbamate and ethylenediaminetetraacetic acid, but not by 8- hydroxyquinoline-5-sulfonic acid. It is suggested that, in mammals at least, the mechanism of action of cysteamine and MEG does not involve the induction of tissue anoxia. No explanation could be offered why cysteamine (containing an SH group) was not systemically protective against epilation nor why cystamine (the S- S form) afforded systemic protection. It is proposed that the protection given the hair follicle by histamine, tryptaraine, and 5-hydroxytryptamine is, at least in part, due to their promotion of tissue hypoxia. (TCO)

• Research Organization: Universite, Liege
• NSA Number: NSA-17-017818
• OSTI ID: 4746440
• Journal Information: Bull. Acad. Roy. Med. Belg., Journal Name: Bull. Acad. Roy. Med. Belg. Vol. Vol: 7
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
AMINES
ANTIHISTAMINICS
BIOLOGY AND MEDICINE
CARBAMATES
CYSTAMINE
CYSTEINE
DEDTC
DRUGS
EDTA
ETHYL RADICALS
HISTAMINE
MEA
MEG
METABOLISM
MICE
ORGANIC SULFUR COMPOUNDS
OXYGEN
RADIATION DOSES
RADIATION EFFECTS
RADIATION PROTECTION
RADIOSENSITIVITY
REGENERATION
SEROTONIN
SKIN
TISSUES
TRYPTAMINES
X RADIATION