LOCAL PROTECTION BY MACROMOLECULES AGAINST EPILATION BY X IRRADIATION (in French)
Various substances were injected under the skin of 8day-old C57 mice which were then exposed to 550-r, wholebody doses of x rays. Thls dose usually caused complete epilation 7 to 9 days later, except around the eyes and mouth and on the feet. Injection of 0.05 to 0.l ml of 10/sup -3/ or 10/sup -4/M Na/sub 2/S/ sub 2/Oa/sub 3/solution subcutaneously 3 min prior t o irradiation protected the skin against epilation at the site of injection. Synovial fluid, a concentrated solution of mucopolysaccharides and protein, also gave marked and consistent protection when injected 3 min before irradiation but was ineffective when injected after irradiation. Thiogel A (an artificial gelatin rich in sulfhydryl groups, molecular wt 10,000) also induced local protection in skin but, when injected intraperitoneally, did not alter the mortality curve. Thiogel A conferred a lower degree of local protection than Na/sub 2/S/sub 2/O/sub 3/ovial fluid. Thiogel B (which contains the same proportion of sulfhydryl groups as Thiogel A but has a molecular wt of 100,000) and heparin also prevented radioinduced epilation when injected subcutaneously before irradiation. These macromolecules, all of which contain sulfhydryl or sulfate groups, appeared to stimulate regeneration of hair follicles as well as protect them against the injurious effect of radiation. (BBB)
- Research Organization:
- Universite, Liege
- NSA Number:
- NSA-17-035472
- OSTI ID:
- 4659043
- Journal Information:
- Arch. Intern. Pharmacodyn., Journal Name: Arch. Intern. Pharmacodyn. Vol. Vol: 139
- Country of Publication:
- Country unknown/Code not available
- Language:
- French
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