THERAPEUTIC EFFECT OF SODIUM CHLOROPHYLLIN ON RADIATION SICKNESS IN ANIMALS

Journal Article · Sun Jan 01 04:00:00 EST 1961 · Uch. Zap., Pyatigorsk. Gos. Farmatsevt. Inst.

OSTI ID:4673341

Levshin, V I

Sodium chlorophyllin (0.5 and 0.05 mg/kg body weight, respectively) was administered to rabbits exposed to x radiation in a dose of 700 r once, and for a period of 12 days after their irradiation. Sixty-day and six-month observations established an increase in the longevity of the animals as compared with the longevity of the control group of rabbits. The intraperitoneal administration of Na chlorophyllin during the period of the development of radiation sickness led to the rapid restoration of the blood indices and body weight of the animals. The life of the animals was prolonged by the fractional administration of Na chlorophyllin after their exposure to x radiation in doses of 1000 r. Eleven of 12 dogs administered Na chlorophyllin for a period of 30 days after irradiation by doses of 500 r were alive on the 45th day (only 5 of the 12 control animals were alive). The therapeutic effect of Na chlorophyllin was expressed in general health improvement, rapid restoration of the number of leucocytes to the initial level, and the restoration to normal of the blood indices and body weight of the animals. (Referativnyy Zhurnal, Farmakologiya i Toksikologiya, No. 7, April 1963)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-031976
• OSTI ID: 4673341
• Journal Information: Uch. Zap., Pyatigorsk. Gos. Farmatsevt. Inst., Journal Name: Uch. Zap., Pyatigorsk. Gos. Farmatsevt. Inst. Vol. Vol: No. 5
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
BLOOD
CHLOROPHYLL
DOGS
DRUGS
EFFICIENCY
LEUCOCYTES
MEDICINE
RABBITS
RADIATION DOSES
RADIATION SICKNESS
RECOVERY
SURVIVAL TIME
THERAPY
WEIGHT
X RADIATION