THE EFFECT OF EXPERIMENTAL ANAEMIA OF RADIOACTIVE Co$sup 60$-CHLOROPHYLLIN, ITS DISTRIBUTION IN THE BODY AND THE THERAPEUTIC EFFECT OF Co-CHLOROPHYLLIN ON ANAEMIA
Journal Article
·
· Keio Journal of Medicine (Japan)
OSTI ID:4071548
When 5 mg of non-radioactive Co-chlorophyllin was injected before irradiation, either two 300 mu g or one 500 mu g injection, inhibition of the decrease in the blood cell counts and promotion of recovery were more marked than in controls receiving no injections. The pre-irradiation administration was more effective than the postirradiation injection. The intravenous injection of non- radioactive Co-chlorophyllin increased the leucocyte count and hemoglobin content in normal rats, but the increase mostly took biphasic curves. The radioactive Co- chlorophyllin was accumulated and was stored for a long time mostly in the RES such as the liver, spleen, and bone marrow, and directly or indirectly stimulated hematopoiesis. Co-chlorophyllin was injected intravenously in 200 cases of malignant tumor treated with irradiation and the changes in the hemoglobin content, erythrocyte, and leucocyte counts were compared with those in 70 cases treated with radiation alone. In the Co-chlorophyllin injected group, the increase in the hemoglobin content, erythrocyte, and leucocyte counts was more marked, and the inhibition of decrease in the blood cell counts was also stronger than in the uninjected group. Fifteen to 25 mg are the optimal individual doses, the optimal total dose being 1000 mg. (Abstr. Japan Med., 1: No. 2, 1960)
- Research Organization:
- Second Tokyo National Hospital, Tokyo
- NSA Number:
- NSA-15-022051
- OSTI ID:
- 4071548
- Journal Information:
- Keio Journal of Medicine (Japan), Journal Name: Keio Journal of Medicine (Japan) Vol. Vol: 36; ISSN KJMEA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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