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Title: THE EFFECT OF EXPERIMENTAL ANAEMIA OF RADIOACTIVE Co$sup 60$-CHLOROPHYLLIN, ITS DISTRIBUTION IN THE BODY AND THE THERAPEUTIC EFFECT OF Co-CHLOROPHYLLIN ON ANAEMIA

Abstract

When 5 mg of non-radioactive Co-chlorophyllin was injected before irradiation, either two 300 mu g or one 500 mu g injection, inhibition of the decrease in the blood cell counts and promotion of recovery were more marked than in controls receiving no injections. The pre-irradiation administration was more effective than the postirradiation injection. The intravenous injection of non- radioactive Co-chlorophyllin increased the leucocyte count and hemoglobin content in normal rats, but the increase mostly took biphasic curves. The radioactive Co- chlorophyllin was accumulated and was stored for a long time mostly in the RES such as the liver, spleen, and bone marrow, and directly or indirectly stimulated hematopoiesis. Co-chlorophyllin was injected intravenously in 200 cases of malignant tumor treated with irradiation and the changes in the hemoglobin content, erythrocyte, and leucocyte counts were compared with those in 70 cases treated with radiation alone. In the Co-chlorophyllin injected group, the increase in the hemoglobin content, erythrocyte, and leucocyte counts was more marked, and the inhibition of decrease in the blood cell counts was also stronger than in the uninjected group. Fifteen to 25 mg are the optimal individual doses, the optimal total dose being 1000 mg. (Abstr. Japan Med., 1: No.more » 2, 1960)« less

Authors:
Publication Date:
Research Org.:
Second Tokyo National Hospital, Tokyo
OSTI Identifier:
4071548
NSA Number:
NSA-15-022051
Resource Type:
Journal Article
Journal Name:
Keio Journal of Medicine (Japan)
Additional Journal Information:
Journal Volume: Vol: 36; Other Information: Orig. Receipt Date: 31-DEC-61
Country of Publication:
Country unknown/Code not available
Language:
English
Subject:
BIOLOGY AND MEDICINE; ANEMIA; BLOOD CELLS; BONE MARROW; CANCER; COBALT 60; ERYTHROCYTES; GLANDS; HEMOGLOBIN; LEUCOCYTES; LIVER; MAN; MEDICINE; QUANTITY RATIO; RADIATION EFFECTS; RADIOTHERAPY; RECOVERY; SPLEEN; TRACER TECHNIQUES

Citation Formats

Tamura, K. THE EFFECT OF EXPERIMENTAL ANAEMIA OF RADIOACTIVE Co$sup 60$-CHLOROPHYLLIN, ITS DISTRIBUTION IN THE BODY AND THE THERAPEUTIC EFFECT OF Co-CHLOROPHYLLIN ON ANAEMIA. Country unknown/Code not available: N. p., 1959. Web.
Tamura, K. THE EFFECT OF EXPERIMENTAL ANAEMIA OF RADIOACTIVE Co$sup 60$-CHLOROPHYLLIN, ITS DISTRIBUTION IN THE BODY AND THE THERAPEUTIC EFFECT OF Co-CHLOROPHYLLIN ON ANAEMIA. Country unknown/Code not available.
Tamura, K. Thu . "THE EFFECT OF EXPERIMENTAL ANAEMIA OF RADIOACTIVE Co$sup 60$-CHLOROPHYLLIN, ITS DISTRIBUTION IN THE BODY AND THE THERAPEUTIC EFFECT OF Co-CHLOROPHYLLIN ON ANAEMIA". Country unknown/Code not available.
@article{osti_4071548,
title = {THE EFFECT OF EXPERIMENTAL ANAEMIA OF RADIOACTIVE Co$sup 60$-CHLOROPHYLLIN, ITS DISTRIBUTION IN THE BODY AND THE THERAPEUTIC EFFECT OF Co-CHLOROPHYLLIN ON ANAEMIA},
author = {Tamura, K},
abstractNote = {When 5 mg of non-radioactive Co-chlorophyllin was injected before irradiation, either two 300 mu g or one 500 mu g injection, inhibition of the decrease in the blood cell counts and promotion of recovery were more marked than in controls receiving no injections. The pre-irradiation administration was more effective than the postirradiation injection. The intravenous injection of non- radioactive Co-chlorophyllin increased the leucocyte count and hemoglobin content in normal rats, but the increase mostly took biphasic curves. The radioactive Co- chlorophyllin was accumulated and was stored for a long time mostly in the RES such as the liver, spleen, and bone marrow, and directly or indirectly stimulated hematopoiesis. Co-chlorophyllin was injected intravenously in 200 cases of malignant tumor treated with irradiation and the changes in the hemoglobin content, erythrocyte, and leucocyte counts were compared with those in 70 cases treated with radiation alone. In the Co-chlorophyllin injected group, the increase in the hemoglobin content, erythrocyte, and leucocyte counts was more marked, and the inhibition of decrease in the blood cell counts was also stronger than in the uninjected group. Fifteen to 25 mg are the optimal individual doses, the optimal total dose being 1000 mg. (Abstr. Japan Med., 1: No. 2, 1960)},
doi = {},
journal = {Keio Journal of Medicine (Japan)},
number = ,
volume = Vol: 36,
place = {Country unknown/Code not available},
year = {1959},
month = {1}
}