Influence of melatonin on erythropoiesis
Estrogens are known to inhibit erythropoiesis in mice. Melatonin inhibits growth of ovary and disrupts the estrous cycle. This report is of studies on the action of melatonin in preventing estrogen inhibition of erythropoiesis. Female mice were given melatonin or its precursor, tryptophan, subjected to hypobaria and finally given either saline, erythropoietin or cobalt salt injections. As expected, melatonin adversely affected development of sex organs. Stimulation of erythropoiesis was measured by Fe-59 incorporation into red cells. Erythropoiesis in melatonin-treated mice was increasingly stimulated with increasing doses of cobalt. The animals also showed greater response to erythropoietin treatment than did mice treated with tryptophan. Thus, the antigonadal action of melatonin suppressed inhibitory action of estrogen on erythropoiesis. Without estrogen influence, the mice were more sensitive to stimulatory action of erythropoietin and cobalt.
- OSTI ID:
- 7313465
- Journal Information:
- J. Elisha Mitchell Sci. Soc.; (United States), Journal Name: J. Elisha Mitchell Sci. Soc.; (United States) Vol. 91:2; ISSN JEMSA
- Country of Publication:
- United States
- Language:
- English
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551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
AMINES
AMINO ACIDS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
ERYTHROCYTES
ERYTHROPOIESIS
ERYTHROPOIETIN
ESTROGENS
ESTROUS CYCLE
EVEN-ODD NUCLEI
FEMALE GENITALS
FEMALES
GONADS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
INDOLES
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MELATONIN
MICE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OVARIES
PRESSURE DROP
PYRROLES
RADIOISOTOPES
RODENTS
STEROID HORMONES
STIMULATION
TRACER TECHNIQUES
TRYPTAMINES
TRYPTOPHAN
UTERUS
VERTEBRATES