Melatonin action during hypobaric hypoxia

Journal Article · · J. Elisha Mitchell Sci. Soc.; (United States)

OSTI ID:7112612

O'Shea, M D; Berkut, M K; Walmer, D K

It is believed that the inhibition of gonadal activity by the pineal gland is mediated by melatonin. The influence of melatonin on erythropoietic stimulation in ethypoxic polycythemic male mice may help in elucidation of the role of testosterone in erythropoiesis. Male mice were injected with melatonin or tryptophan and plethora was induced by hypobaric hypoxia. Mice were then injected with either saline, erythropoietin or cobalt chloride. Fe-59 incorporation into hemoglobin and red blood cells was measured. Melatonin-treated animals were slightly less responsive to cobalt, but responded to exogenous erythropoietin as did animals not given melatonin. A direct augmentation of erythropoietin by testosterone probably does not occur. Potentiation by testosterone of the increase in plasma erythropoietin may not be ruled out.

• OSTI ID: 7112612
• Journal Information: J. Elisha Mitchell Sci. Soc.; (United States), Journal Name: J. Elisha Mitchell Sci. Soc.; (United States) Vol. 91:2; ISSN JEMSA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
AMINES
AMINO ACIDS
ANIMALS
ANOXIA
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BLOOD PLASMA
BODY FLUIDS
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
ERYTHROCYTES
ERYTHROPOIESIS
EVEN-ODD NUCLEI
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MALES
MAMMALS
MELATONIN
MICE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRROLES
RADIOISOTOPES
RODENTS
STIMULATION
TRACER TECHNIQUES
TRYPTAMINES
TRYPTOPHAN
VERTEBRATES