Response of gonadectomized mice to erythropoietic stimulation

Journal Article · · J. Elisha Mitchell Sci. Soc.; (United States)

OSTI ID:7313468

Berkut, M K; Walmer, D K; O'Shea, M D

Red blood cell production is regulated by humoral factors, in particular erythropoietin, acting on erythroid stem cells in the bone marrow. Higher red blood cell mass in males than in females has been attributed to erythropoietic stimulation by testosterone. The mechanism by which this stimulus occurs is not known. Estrogens generally inhibit erythropoietin production; however, estrogen-sensitized erythroid stem cells in female bone marrow are more sensitive to stimulation than are those in the male. Kinetics of erythropoiesis and responsiveness of castrated male mice to the stimulus of bleeding were investigated using radioiron (Fe 59) as a tracer. Positive erythropoietic response occurred 72 hours after bleeding. Specific activity of hemoglobin was the same in castrated as in normal males previously treated with erythropoietin. Kinetics of hemoglobin synthesis and red blood cell production apparently was not altered by castration. The early production of red cells and hemoglobin leaves doubt that testosterone is the sole regulator. Hemoglobin synthesis in the absence of testosterone suggests that it is not normally required. Possibly, a yet unidentified cholesterol metabolite, having neither estrogenic nor androgenic potencies could be an accessory erthropoietic agent.

• OSTI ID: 7313468
• Journal Information: J. Elisha Mitchell Sci. Soc.; (United States), Journal Name: J. Elisha Mitchell Sci. Soc.; (United States) Vol. 91:2; ISSN JEMSA
• Country of Publication: United States
• Language: English

Related Subjects

550200* -- Biochemistry
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANDROGENS
ANDROSTANES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY FLUIDS
BONE MARROW CELLS
CARBOXYLIC ACIDS
CASTRATION
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
ERYTHROCYTES
ERYTHROPOIESIS
ERYTHROPOIETIN
ESTROGENS
EVEN-ODD NUCLEI
GLOBIN
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IRON 59
IRON ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KETONES
KINETICS
MALES
MAMMALS
MEDICINE
MICE
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
STEROID HORMONES
STEROIDS
STIMULATION
SURGERY
SYNTHESIS
TESTOSTERONE
TRACER TECHNIQUES
VERTEBRATES