Split dose studies on the erythropoietic effects of cadmium

Journal Article · Mon Jun 01 04:00:00 EDT 1992 · Bulletin of Environmental Contamination and Toxicology

DOI:https://doi.org/10.1007/BF00201146· OSTI ID:35669

Hogan, G R ^[1]; Razniak, S L ^[2]

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1. St. Cloud State Univ., MN (United States)
2. East Texas State Univ., Commerce, TX (United States)

The processes of red blood cell production and release, i.e., erythropoiesis, are complex and involve a series of cell divisions and maturation phases during which hemoglobin is synthesized. The formation of hemoglobin is an integral process and functions as one of the factors that control the rate and extent of erythropoiesis. Therefore, exogenous and endogenous factors which affect the synthesis of hemoglobin would secondarily affect the rate and extent of the erythropoietic process. Incorporation of radioactively labeled iron ({sup 59}Fe) into the hemoglobin of erythrocyte precursor cells in the process of hemoglobin production, is a precise measurement of erythropoiesis. Another widely used indicator of the rate and extent of hemoglobin synthesis, and thus, erythropoiesis, is the activity level of the enzyme, delta-aminolevulinic acid dehydratase (ALAD). This enzyme plays a crucial role in hemoglobin formation by promoting the condensation of two moles of aminolevulinic acid to form one mole of porphobilinogen. The degree of ALAD activity and/or its availability to perform its coupling function would, of course, affect the synthesis of hemoglobin which in turn would influence the total erythropoietic progression. The purposes of the studies here were to compare the erythropoietic effects of a single dosage of cadmium to split dosages. 19 refs., 21 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 35669
• Journal Information: Bulletin of Environmental Contamination and Toxicology, Journal Name: Bulletin of Environmental Contamination and Toxicology Journal Issue: 6 Vol. 48; ISSN 0007-4861; ISSN BECTA6
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AMINOLEVULINIC ACID
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
CADMIUM
ERYTHROPOIESIS
HEMOGLOBIN
MICE