Effect of triethyl lead chloride on delta-aminolevulinic acid dehydratase

Journal Article · Wed Jan 01 04:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530900· OSTI ID:5001464

Bondy, S C

The effect of various organic metal compounds on delta-aminolevulinic acid dehydratase (ALAD, porphobilinogen synthetase) activity has been studied. Various organic tin and lead compounds have little effect on this enzyme. However, triethyl lead chloride has a potency similar to that of inorganic lead nitrate in inhibiting ALAD both for in vitro study and after in vivo dosing. Liver and blood ALAD have a similar sensitivity to lead compounds, which is reduced in the presence of zinc. Trimethyl lead chloride inhibits ALAD in vitro to a lesser extent. The results suggest that amphiphilic organic lead compounds may directly inhibit ALAD without prior degradation to inorganic lead. The diffusibility and persistence of triethyl lead combine to make it an especially hazardous lead compound.

• Research Organization: Univ. of California, Irvine
• OSTI ID: 5001464
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 18:4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARBON-OXYGEN LYASES
CHLORIDES
CHLORINE COMPOUNDS
DATA
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
HALIDES
HALOGEN COMPOUNDS
HYDRO-LYASES
IN VITRO
INFORMATION
INHIBITION
LEAD CHLORIDES
LEAD COMPOUNDS
LEAD HALIDES
LYASES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
SENSITIVITY
TOXICITY