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delta-aminolevulinic acid dehydratase in low level lead exposure

Journal Article · · Arch. Environ. Health; (United States)
; ; ; ; ;

No statistically significant correlation was observed between log delta-aminolevulinic acid dehydratase (ALAD) activity and blood lead levels (Pb-B) in rural or urban habitants (P is greater than .5 and P is greater than .1, respectively) in whom no occupational source of lead was known. However, when the values of the two groups were pooled, there was a fairly good negative correlation (r = -0.509, P is less than .01). Stepwise correlation coefficient analysis indicated the existence of a threshold value of Pb-B (around 15 ..mu..g/100 ml) below which ALAD activity has no orderly relationship with the Pb-B. In contrast with married couples, parents and their children showed a remarkably high interrelationship in values of ALAD. It is concluded that in low level lead exposure primarily genetic factors influence the activity of ALAD and, thus, ALAD is useful for the evaluation of lead exposure only when the lead level is higher than the threshold.

Research Organization:
Tokyo Univ.
OSTI ID:
7223053
Journal Information:
Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 31:4; ISSN AEHLA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
AMINOLEVULINIC ACID
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL VARIABILITY
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CATALYSIS
CHRONIC INTAKE
COMPARATIVE EVALUATIONS
CORRELATIONS
ELEMENTS
ENZYME INHIBITORS
ENZYMES
ERYTHROCYTES
GENETIC VARIABILITY
HAZARDS
HEALTH HAZARDS
HUMAN POPULATIONS
INTAKE
LEAD
MAMMALS
MAN
METABOLISM
METALS
MONITORING
ORGANIC ACIDS
ORGANIC COMPOUNDS
POPULATIONS
PRIMATES
PROGENY
RURAL POPULATIONS
URBAN POPULATIONS
VERTEBRATES
ZINC