Relationship between urinary delta-aminolevulinic acid excretion and the inhibition of red cells delta-aminolevulinate dehydratase by lead

Journal Article · Thu Aug 01 00:00:00 EDT 1974 · Clin. Toxicol.; (United States)

DOI:https://doi.org/10.3109/15563657408988001· OSTI ID:7349132

Lauwerys, R; Buchet, J P; Roels, H A; Materne, D

83 male workers occupationally exposed to lead and 84 control workers were investigated to find out the degree of delta-aminolevulinic acid dehydratase (ALAD) inhibition by lead which causes a build-up of delta-aminolevulinic acid (ALA) in the body and a resulting increase in its urinary excretion. The critical level was found to be the point at which ALAD activity is reduced to 30 percent of that estimated for a blood lead level of 10 ..mu..g percent, viz, a blood lead level of 45 ..mu..g percent.

• OSTI ID: 7349132
• Journal Information: Clin. Toxicol.; (United States), Journal Name: Clin. Toxicol.; (United States) Vol. 7:4; ISSN CTOXA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
AMINOLEVULINIC ACID
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
ELEMENTS
ENZYMES
HAZARDS
HEALTH HAZARDS
INDUSTRIAL MEDICINE
LEAD
MEDICINE
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PUBLIC HEALTH
TOXICITY
URINE
WASTES