Different behaviors of erythrocyte delta-aminolevulinic acid dehydratase: a comparison study between lead workers and normals

Journal Article · Sat Mar 01 04:00:00 EDT 1975 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1975.10666664· OSTI ID:7351195

Tomokuni, K

delta-Aminolevulinic acid dehydratase (ALAD) behaves differently depending on whether subjects have been occupationally exposed to lead or not. Erythrocyte ALAD in lead blood is activated about 3.6-fold the initial level (normal blood: 1.3-fold) by heating the haemolysates at 60/sup 0/C for 5 min. The optimum in the pH-activity curve shifts from pH 6.0 to pH 6.6, whereas it hardly changes in normal blood. These findings suggest that the inhibitory effect of lead on ALAD is partly reversed by a lower incubation pH, and completely so by heating the haemolysates at 60/sup 0/C for 5 min.

• OSTI ID: 7351195
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 30:3; ISSN AEHLA
• Country of Publication: United States
• Language: English

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54 ENVIRONMENTAL SCIENCES
550600 -- Medicine
551000 -- Physiological Systems
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AIR POLLUTION
AMINO ACIDS
AMINOLEVULINIC ACID
BIOASSAY
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
ENZYMES
ERYTHROCYTES
HAZARDS
HEALTH HAZARDS
INDUSTRIAL MEDICINE
LEAD
MEDICINE
METALS
OCCUPATIONAL DISEASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PH VALUE
POLLUTION
PUBLIC HEALTH
QUANTITATIVE CHEMICAL ANALYSIS