delta. -aminolevulinic acid dehydratase test for lead exposure

Journal Article · Fri Nov 01 04:00:00 EST 1974 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1974.10666587· OSTI ID:7341173

Tomokuni, K

The delta-aminolaevulinic acid dehydratase (ALAD) test is usually performed with incubation at the pH level found in normal human blood. Available data demonstrate that while the normal erythrocyte ALAD activity has its pH optimum at 6.8 (that in normal human blood), in occupational lead exposure the ALAD activity has its pH optimum at 6.0. In this study the ALAD assay was performed by simultaneous incubation at the normal and at the lower pH value and the results expressed as an activity ratio in addition to the activity itself. The report discusses whether the use of the activity ratio in the ALAD test is more effective in evaluating the level of occupational lead exposure.

• OSTI ID: 7341173
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 29:5; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
AMINOLEVULINIC ACID
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
ELEMENTS
ENZYMES
HAZARDS
HEALTH HAZARDS
INDUSTRIAL MEDICINE
LEAD
MEDICINE
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PH VALUE
PUBLIC HEALTH
SAMPLING