Methylmercury movements across the perfused guinea pig placenta in late gestation. [Tritium, /sup 125/I, /sup 203/Hg]

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(77)90184-3· OSTI ID:7313447

Kelman, B J; Sasser, L B

Placentas from guinea pigs between 61 and 63 days gestation were perfused from the fetal side in situ at rates ranging from 0.35 to 4.54 ml/min. The dam was injected intravenously with tracer quantities of tritiated water and radiolabeled mercury in the form of methylmercuric chloride. Maternal plasma and the perfusate samples were analyzed for radiolabeled mercury and tritiated water, and corrections were made for net water flows by using radioiodinated serum albumin. Radiomercury and tritium clearances were therefore measured concurrently. The clearance of tritiated water was a linear function of perfusion rate. The relationship between tritium clearance and perfusion rate for all experiments combined was described by the equation: y = 0.16 + 0.54x, where y is tritium clearance and x is perfusion rate. Clearance of radiolabeled mercury measured 0.15 +- 0.01 ml/min (mean +- SE). No significant relationship between radiomercury and tritium clearance was detected. It appears that calcium and low concentrations of methylmercury may move across the placenta by the same or similar mechanisms.

• Research Organization: Comparative Animal Research Lab., Oak Ridge, TN
• OSTI ID: 7313447
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 39; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
CALCIUM
CLEARANCE
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FETAL MEMBRANES
GUINEA PIGS
HEAVY NUCLEI
HYDROGEN ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
MAMMALS
MEMBRANES
MERCURY 203
MERCURY ISOTOPES
METALS
METHYLMERCURY
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
PERFUSED ORGANS
PLACENTA
PREGNANCY
RADIOISOTOPES
REACTION KINETICS
RODENTS
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES