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Transplacental movements of inorganic lead from mother to fetus

Journal Article · · Proc. Soc. Exp. Biol. Med.; (United States)
;
Placental transport of lead in the guinea pig was measured by perfusing the fetal circulation of placentas (at 60 days of gestation) in situ. The clearance of lead from mother to fetus was linearly related to umbilical flow rate and measured 0.047 +- 0.004 ml/min at an umbilical flow rate of 2.5 ml/min. Our data indicate that lead crosses the placenta from the maternal circulation to the fetal circulation at a lower clearance rate than either cadmium or methylmercury but at a greater rate than inorganic mercury.
Research Organization:
Comparative Animal Research Lab., Oak Ridge, TN
OSTI ID:
5260585
Journal Information:
Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 163:2; ISSN PSEBA
Country of Publication:
United States
Language:
English

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Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
CADMIUM
CLEARANCE
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
ELEMENTS
EVEN-EVEN NUCLEI
EXPERIMENTAL DATA
FETAL MEMBRANES
FETUSES
FLOW RATE
GUINEA PIGS
HEAVY NUCLEI
HYDROGEN ISOTOPES
INFORMATION
ISOLATED VALUES
ISOTOPES
LABELLED COMPOUNDS
LEAD
LEAD 210
LEAD ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
MERCURY
METABOLISM
METALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
PLACENTA
PREGNANCY
RADIOISOTOPES
RESPONSE MODIFYING FACTORS
RODENTS
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES