Movements of benzo(a)pyrene across the hemochorial placenta of the guinea pig

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-169-41307· OSTI ID:5524258

Kelman, B J; Springer, D L

In an effort to determine fetal exposure resulting from maternally administered benzo(a)pyrene (BaP), the clearance of radiolabeled BaP from mother to fetus was measured across the hemochorial placenta of the guinea pig at 60 days of gestation. Using techniques previously reported for other toxic materials, the fetal circulation of the placenta was isolated. BaP injected into the maternal circulation, and the concentration of BaP determined in the perfusate. The clearance of BaP from mother to fetus was high following intravenous injection. Clearances appeared to be a function of umbilical blood flow, and ranged from 0.59 to 2.40 ml/min at an umbilical flow of 2.5 ml/min. Since clearances of BaP approximated those obtained for tritiated water, it is apparent that circulating BaP gains easy access to the fetus.

• Research Organization: Pacific Northwest Laboratory, Richland, WA
• OSTI ID: 5524258
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 169:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOPYRENE
BIOCHEMICAL REACTION KINETICS
CONDENSED AROMATICS
DATA
DISTRIBUTION
EXPERIMENTAL DATA
FETAL MEMBRANES
FETUSES
GUINEA PIGS
HYDROCARBONS
INFORMATION
KINETICS
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
NUMERICAL DATA
ORGANIC COMPOUNDS
PLACENTA
REACTION KINETICS
RODENTS
TISSUE DISTRIBUTION
VERTEBRATES