Inorganic mercury movements across the perfused guinea pig placenta in late gestation. [/sup 125/I, /sup 3/H]

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/S0041-008X(77)80019-7· OSTI ID:6503062

Kelman, B J

Since most studies of mercury transfer to the fetus are confounded by an inability to separate fetal uptake from placental transport, mercury transport across perfused guinea pig placentas (61 to 63 days gestation) was measured in situ. The fetal side of the placenta was perfused at rates ranging from 0.49 to 4.10 ml/min. The dam was injected iv with trace quantities of tritiated water (to indicate changes in maternal blood flow to the placenta) and radiolabeled mercury in the form of mercuric chloride. Maternal plasma and perfusate samples were analyzed for radiolabeled mercury and tritiated water after corrections were made for net water flow by using radioiodinated serum albumin. The clearance of tritiated water was a linear function of perfusion rate described for the pooled data from all perfusions by the equation: y = 0.67 + 1.61x, where y is tritium clearance and x is perfusion rate. No significant relationships between radiomercury clearance and perfusion rate were detected in this study. The clearance of radiolabeled mercury measured 0.012 +- 0.001 ml/min (mean +- SE), at least one order of magnitude less than previously reported values of methylmercury clearance (p < 0.001). The differences in clearances between organic and inorganic mercury were sufficiently great to account for reported differenced in fetal absorption of organic and inorganic mercury.

• Research Organization: Comparative Animal Research Lab., Oak Ridge, TN
• OSTI ID: 6503062
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 41; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DIFFUSION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FETAL MEMBRANES
FETUSES
GUINEA PIGS
HYDROGEN ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANES
MERCURY
MERCURY ISOTOPES
METABOLISM
METALS
NUCLEI
ODD-EVEN NUCLEI
PERFUSED TISSUES
PLACENTA
PREGNANCY
RADIOISOTOPES
RODENTS
TISSUES
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES