Transplacental differences in Ca, Na, K, and electropotential in the guinea pig
Technical Report
·
OSTI ID:5849899
The fetal side of hemochorial placentas from guinea pigs between 58 and 62 days gestation were perfused in situ. Concurrent measurements were made of the clearances of radiocalcium and tritiated water from maternal to fetal circulation of the placenta, transplacental potential difference (TPD), maternal plasma and perfusate Ca, Na, and K concentrations, maternal blood pressure, gross permeability of albumin in the placenta, and net water movements. Movement of Ca from dam to fetus appeared to occur against an electrochemical gradient and was not associated with the movements of Na and K across the placenta. A negative correlation between perfusate Na and K concentrations, not dependent on maternal plasma Na and K concentrations and abolished by high concentrations of Ca in the fetal circulation of the placenta, strongly supports the concept of a Na-K exchange mechanism in the placenta directed so that K is moved against a concentration gradient towards the dam. There was no evidence that the TPD existed at the site of maternal-fetal exchange for Ca, Na, or K.
- Research Organization:
- Pacific Northwest Lab., Richland, WA (USA)
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 5849899
- Report Number(s):
- PNL-SA-9839; ON: DE83015090
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METALS
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM
CALCIUM 45
CALCIUM ISOTOPES
CLEARANCE
DATA
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FETAL MEMBRANES
GUINEA PIGS
HYDROGEN ISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
METALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
PERFUSED TISSUES
PERMEABILITY
PLACENTA
POTASSIUM
RADIOISOTOPES
RODENTS
SODIUM
TISSUES
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES
59 BASIC BIOLOGICAL SCIENCES
ALKALI METALS
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM
CALCIUM 45
CALCIUM ISOTOPES
CLEARANCE
DATA
DAYS LIVING RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FETAL MEMBRANES
GUINEA PIGS
HYDROGEN ISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
METALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
PERFUSED TISSUES
PERMEABILITY
PLACENTA
POTASSIUM
RADIOISOTOPES
RODENTS
SODIUM
TISSUES
TRACER TECHNIQUES
TRITIUM
VERTEBRATES
YEARS LIVING RADIOISOTOPES