Influence of acute tissue injury on in vitro incorporation of /sup 65/Zn by sheep erythrocytes. [Beta particles]
Labeled zinc incorporation by etythrocytes of diseased or injured animals may reveal zinc-status information when borderline zinc deficiencies exist. The /sup 65/Zn uptake by red blood cells of skin-irradiated sheep was much greater than that of cells from control sheep, and factors affecting this uptake were studied. The increased /sup 65/Zn uptake was not influenced by the change in packed cell volume, nor could the uptake be altered by extracorporeal irradiation of the red blood cells. The nominal rate of /sup 65/Zn uptake during a 10-hr incubation period was 0.6% per hour for control cells and 1.4% per hour for cells from injured sheep. Hypoalbuminemia and hyperglobulinemia resulted from the irradiation injury, and this change in plasma composition could account for part, but not all, of the differences in uptake between cells from injured and control sheep. Significant differences between the cells from these two sources were still observed when the influence of the plasma was removed. These differences could be due to an increased zinc permeability resulting from injury sustained by the cells as they circulated through injured tissue, or may be associated with the role of zinc in wound healing.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 7306667
- Journal Information:
- J. Anim. Sci.; (United States), Journal Name: J. Anim. Sci.; (United States) Vol. 41:6; ISSN JANSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA PARTICLES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
IN VITRO
INJURIES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NUCLEI
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RUMINANTS
SHEEP
SKIN
TISSUES
UPTAKE
VERTEBRATES
ZINC 65
ZINC ISOTOPES