Influence of x-irradiation on zinc-65 uptake of testes in mice
Twenty-four hours after a single whole-body x-irradiation (400 r), a significant decrease was observed in Zn65 uptake of testes in mice. The decrease was statistically significant in terms of percentages of the injected Zn65 per unit weight of either wet or dried tissue. Splenic weight decreased approximately by half, but Zn65 concentration in spleen remained unchanged or slightly increased. Zn65 uptake of seminal vesicles, kidneys, and submaxillary glands was not influenced by the irradiation. Similar depressant effects of x-irradiation on the testicular Zn65 uptake was observed after a single local irradiation to scrotum and hind legs (1000 r). Localized irradiation to head and forelegs had less influence on testicular zinc uptake. The fact suggests that the effect was mainly due to a direct effect of the irradiation on the testes. Nineteen days after the localized irradiation to scrotum and hind legs (1000 r), the weight of the testes decreased markedly. Zn65 uptake of the damaged testes, however, did not differ from that of the testes in control animals when compared in terms of radioactivity per unit weight of wet or dry organ. The possibility is discussed that the decrease in testicular zinc uptake observed 24 hours after x-irradiation is due to a change in the affinity of the interstitial cells to zinc rather than a change in that of germinal cells in the testes.
- Research Organization:
- National Inst. of Radiological Sciences, Chibashi, Japan
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-033725
- OSTI ID:
- 4659804
- Journal Information:
- Radiation Res., Journal Name: Radiation Res. Vol. Vol: 19
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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