Uptake of /sup 65/Zn in the mouse fetus as a function of gestational age

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574519· OSTI ID:7314446

Matsusaka, N

Radioactive zinc (/sup 65/Zn) uptake in the mouse fetus was studied as a function of time after administration. The fetal uptake of /sup 65/Zn increased markedly with time after administration to the pregnant mice of gestation period Day 17, i.e., from 0.28 percent of the dose 30 min after administration to 2.25 percent of the dose 24 hr after administration. The similar increasing tendency of /sup 65/Zn uptake was also observed in the fetal membranes, whereas the placental uptake decreased with time. The pregnant mice of Days 12, 15, 17, and 18 of gestation received a single dose of /sup 65/Zn, and the fetal uptake was observed daily until parturition. The fetal uptake of /sup 65/Zn increased with progression of gestation period after administration, and the /sup 65/Zn concentrations in the fetus exceeded those in the maternal blood. From these observations, it was assumed that there was no placental barrier against /sup 65/Zn transfer from dam to fetus in mice.

• Research Organization: Iwate Univ., Morioka, Japan
• OSTI ID: 7314446
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 69:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FETAL MEMBRANES
FETUSES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MEMBRANES
MICE
NUCLEI
PLACENTA
PREGNANCY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
TIME DEPENDENCE
UPTAKE
VERTEBRATES
ZINC 65
ZINC ISOTOPES