A study of placental transfer mechanisms in nonhuman primates using (/sup 14/C)phenylalanine

Journal Article · Sun Jan 31 23:00:00 EST 1982 · Obstet. Gynecol.; (United States)

OSTI ID:6880052

Pueschel, S M; Boylan, J M; Jackson, B T; Piasecki, G J

Placental transfer mechanisms were investigated in pregnant Macaca Fascicularis and Macaca mulatta during the gestational age of 120 to 130 days. These primates underwent an operative procedure that allowed continuous fetal blood sampling. The administration of (/sup 14/C)phenylalanine into the maternal circulation revealed a significant increase of radioactive material in the fetal circulation, indicating an active placental transport mechanism unidirectional to the fetus. When (/sup 14/C)phenylalanine was injected into the fetus, radioactive aromatic amino acids in the maternal circulation increased only slightly over time, resembling a simple diffusion process.

• Research Organization: Department of Pediatrics, Rhode Island Hospital, Providence
• OSTI ID: 6880052
• Journal Information: Obstet. Gynecol.; (United States), Journal Name: Obstet. Gynecol.; (United States) Vol. 59:2; ISSN OBGNA
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
FETAL MEMBRANES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MACACUS
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
MONKEYS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PHENYLALANINE
PLACENTA
PREGNANCY
PRIMATES
VERTEBRATES