Copper transport from mother to fetus, at the end of gestation, in rats

Conference · Sun Feb 25 23:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5481631

Lee, S H; Madani, N; Linder, M C ^[1]

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1. California State Univ., Fullerton (United States)

The authors have followed the fate of {sup 67}Cu in pregnant rats, from 1-4 days before the end of gestation, after its intravenous infusion in the form of in vivo labeled ceruloplasmin (Cp) or {sup 67}Cu(II)-treated rat serum. One and 4 hours after administration, radioactivity administered as Cp was still with Cp in the maternal circulation and that of ionic copper was still associated with transcuprein and albumin (Tc and Alb). On the basis of % dose, Cp appeared to be more effective than Tc + Alb as a source of copper for the placenta and fetus. In contrast, maternal liver took up less {sup 67}Cu from Cp than from Tc + Alb. Four hours after administration, about 8% of the {sup 67}Cu administered as Cp had been taken up by the placenta and fetuses compared with about 2% in the case of {sup 67}Cu from Tc + Alb. The amounts of {sup 67}Cu in fetuses and fetal liver increased with time. Initial trials indicated that Cu administered as Cp became attached mainly to Tc in the fetal circulation, but was also associated with Alb and with Cp, at least by 4 hours. mRNA for ceruloplasmin was detected in maternal liver, placenta, and fetal liver, where it was present primarily on ER-bound (rather than free) polyribosomes. They conclude that normally ceruloplasmin is probably the main source of copper for the fetus, at least in the rat, although transcuprein and albumin can substitute as sources; and after entering the placenta, copper from ceruloplasmin may be transferred to transcuprein and albumin in the fetal circulation, from whence it enters the liver for storage and incorporation into fetal ceruloplasmin.

• OSTI ID: 5481631
• Report Number(s): CONF-9004153--
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Vol. 4:3; ISSN 0892-6638; ISSN FAJOE
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD SERUM
BODY
CERULOPLASMIN
COMPLEXES
COPPER
COPPER 67
COPPER COMPLEXES
COPPER COMPOUNDS
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELEMENTS
FETAL MEMBRANES
FETUSES
GLANDS
GLOBULINS
GLOBULINS-ALPHA
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIVER
MEMBRANE TRANSPORT
MEMBRANES
MESSENGER-RNA
METABOLISM
METALLOPROTEINS
METALS
NUCLEI
NUCLEIC ACIDS
NUTRITION
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RNA
TRACER TECHNIQUES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS