Fetal translocation and metabolism of PAH obtained from coal fly ash given intratracheally to pregnant rats

Journal Article · Wed Jan 01 04:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530885· OSTI ID:5115999

Srivastava, V K; Chauhan, S S; Srivastava, P K; Kumar, V; Misra, U K

Polycyclic aromatic hydrocarbons (PAH) were extracted from coal fly ash collected from the electrostatic precipitator of a thermal power plant. The PAH extract was given intratracheally daily to pregnant rats (2 mg/100 g body weight) on d 18 and 19 of gestation. In addition of d 19 of gestation rats were also given (/sup 4/H)benzo(a)pyrene intratracheally. Rats were sacrificed on d 20 of gestation, and the distribution of (/sup 3/H)benzo(a)pyrene radioactivity and PAH of coal fly ash was studied in maternal lung, liver, and placenta, as well as in the liver and lung of the fetus. The radioactivity of intratracheally given benzo(a)pyrene was found in liver (68%), placenta (4%), fetal lung (1.9%), and fetal liver (1.4%) of maternal lung. Intratracheally administered PAH of coal fly ash were translocated to maternal liver and placenta, as well as to the liver and lung of the fetus. PAH of coal fly ash were also metabolized to several minor and major metabolites by maternal lung, liver, and placenta, as well as by the maternal fetal liver and lung. Some of the PAH metabolites in lung and liver were common; however, the major metabolite of liver, M-16, was different from the major metabolite M-16 of lung. The major PAH metabolite of placenta, M-15, and fetal liver, F-12, were common PAH metabolites. M-2 and M-6 of the placenta and F-5 and F-10 of the fetal lung were also common.

• Research Organization: Univ. of Delhi, India
• OSTI ID: 5115999
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 18:3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMALS
AROMATICS
ASHES
BODY
CARBONACEOUS MATERIALS
COAL
COMPARATIVE EVALUATIONS
CONTAMINATION
DATA
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTROSTATIC PRECIPITATORS
ENERGY SOURCES
EQUIPMENT
EXPERIMENTAL DATA
FETAL MEMBRANES
FETUSES
FLY ASH
FOSSIL FUELS
FUELS
GLANDS
HYDROCARBONS
INFORMATION
INTRATRACHEAL ADMINISTRATION
LIVER
LUNGS
MAMMALS
MATERIALS
MEMBRANE TRANSPORT
MEMBRANES
METABOLISM
METABOLITES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
POLLUTION CONTROL EQUIPMENT
POLYCYCLIC AROMATIC HYDROCARBONS
POWER PLANTS
RATS
RESIDUES
RESPIRATORY SYSTEM
RODENTS
THERMAL POWER PLANTS
TISSUE DISTRIBUTION
VERTEBRATES
WASTES