Disposition of cefixime in the material-fetal unit after an i. v. dose to pregnant rats

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5507824

Halperin-Walega, E; Barr, A; Tonelli, A P; Shin, K; Batra, V K

Cefixime, a potent, broad spectrum oral cephalosporin, is currently undergoing clinical trials. To determine the extent of transfer of cefixime across the placenta to the fetus, a single dose of 17.8 mg/kg /sup 14/C-cefixime was administered to rats on day 18 of gestation via the caudal vein. Maternal serum and urine, fetal plasma and tissues, and placentae were sampled at appropriate times after dosing. Separate rats were subjected to whole body autoradiography. The half-life for elimination of radioactivity from both maternal serum and placentae was 6.9 hours. Elimination from fetal plasma and tissues was somewhat longer, 12.5 and 13.7 hours, respectively. However, based on a comparison of area under the curve, relative to maternal dose, exposure of the fetuses to cefixime was far less than that of placentae. Peak radioactivity in fetal plasma occurred at 2 hours and was less than 2% of the maternal peak at 0.5 hours after dosing. Whole body autoradiography showed the greatest radioactivity in maternal liver, kidney and intestines. Somewhat less radioactivity appeared in placentae and virtually none could be visualized within the amniotic sac. Overall, the data indicate that exposure of the rat fetus to cefixime after a single maternal dose is limited by the placenta.

• Research Organization: American Cyanamid Co., Pearl River, NY
• OSTI ID: 5507824
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
AUTORADIOGRAPHY
BIOLOGICAL HALF-LIFE
BODY
CARBON 14 COMPOUNDS
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
FETAL MEMBRANES
FETUSES
GASTROINTESTINAL TRACT
GLANDS
INJECTION
INTAKE
INTESTINES
INTRAVENOUS INJECTION
KIDNEYS
LABELLED COMPOUNDS
LIVER
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
ORGANS
PLACENTA
PREGNANCY
RATS
RODENTS
TISSUE DISTRIBUTION
VERTEBRATES