Fetal uptake of cerium-144--praseodymium-144 after injection of its chelates to pregnant rat
On the 17th day of pregnancy, albino rats were injected intravenously with /sup 144/Ce-/sup 144/Pr (designated hereinafter as /sup 144/Ce wit h the / sup 144/Pr daughter assumed to be in equilibrium) chloride, citrate, nttrilotriacetate (NTA), or ethylenediaminetetraacetate (EDTA) and sacrificed at intervals up to 4 days later. The radioactivity of fetuses, placentae, amniotic fluid, maternal blood and maternal femora was measured. Deposition of the four / sup 144/Ce compounds in the fetuses was small: the greatest deposition, 0.013% of the injected dose deposited in one fetus, was observed 4 days after injection of / sup 144/CeEDTA. The radioactivity of the fetuses generally increased with time after injection of /sup 144/CeCl/sub 3/ or /sup 144/CeEDTA. Deposition of /sup 144/Ce in the fetuses was greatest after injection of /sup 144/CeEDTA or /sup 144/ Ce-citrate and least after injection of /sup 144/CeC l/sub 3/ or /sup 144/CeNTA, but the differences were not always significant. Deposition of /sup 144/Ce in the placenta was greatest after injection of /sup 144/CeEDTA. Deposition of /sup 144/Ce in maternal bone was significantly greater after injection of /sup 144/Ce chelates than after injection of /sup 144/CeCl/sub 3/. (auth)
- Research Organization:
- Research Inst. of Industrial Hygiene and Occupational Diseases, Bratislava
- NSA Number:
- NSA-29-005373
- OSTI ID:
- 4403790
- Journal Information:
- Health Phys., v. 25, no. 6, pp. 575-580, Journal Name: Health Phys., v. 25, no. 6, pp. 575-580; ISSN HLTPA
- Country of Publication:
- United Kingdom
- Language:
- English
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