Modification of immunological potential by ultraviolet radiation. II. Generation of suppressor cells in short-term uv-irradiated mice. [Mice]

Journal Article · Mon Aug 01 04:00:00 EDT 1977 · Transplantation; (United States)

OSTI ID:7300325

Spellman, C W; Daynes, R A

When normal mice are exposed for short periods to ultraviolet light (uv), they support the progressive growth of transplanted syngeneic uv-induced tumors. Normal nonirradiated mice almost always reject these tumor implants. The uv-mediated suppression of the antitumor response can be adoptively transferred to normal syngeneic mice with lymphoid cells derived from short-term uv-irradiated donors. Transfer of the suppressive effect is dosage dependent and also appears to require the presence of viable T lymphocytes. Suppressive activity was observed in both the spleen and thymus of uv-irradiated donors. In the preceding paper we have established that uv irradiation does not cause a general depression of testable immune functions. Collectively these data suggest that short-term uv irradiation of mice leads to an increase in suppressor cell activity, thereby causing an inhibition in the host's ability to respond to an antigenic uv-induced tumor. The possible role of this phenomenon in the mechanism of uv carcinogenesis is discussed.

• Research Organization: Univ. of Utah, Salt Lake City
• OSTI ID: 7300325
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 24:2; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENESIS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MICE
NEOPLASMS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
TRANSPLANTS
ULTRAVIOLET RADIATION
VERTEBRATES