Further characterization of immunological unresponsiveness induced in mice by ultraviolet radiation. II. Studies on the origin and activity of ultraviolet-induced suppressor lymphocytes

Journal Article · Sun Feb 01 04:00:00 EST 1981 · Transplantation; (United States)

OSTI ID:5584198

Thorn, R M; Fisher, M S; Kripke, M L

Researchers are studying the development and mode of action of suppressor T cells induced by ultraviolet (uv) radiation, which prevent the rejection of syngeneic uv-induced tumors. Suppressor cells were induced in C3H mice by exposure to FS40 sunlamps for 1 hr, three times per week for 3 months. Neither thymectomy nor splenectomy prior to uv irradiation prevented the development of these suppressor T cells in other lymphoid tissues. The uv-induced suppressor cells functioned when injected s.c. with mixtures of normal lymphocytes and tumor cells in a Winn-type assay in immunodeficient recipients. When uv T cells were mixed with syngeneic uv-induced tumor cells they did not increase the incidence or growth rate of the tumors relative to tumor cells alone, suggesting that the suppressor cells function by interacting with normal lymphocytes and not by directly stimulating tumor growth. Although the suppressor cells were effective in vivo when injected i.v. or when injected locally with normal lymphocytes, they did not suppress cytotoxic effector lymphocytes in a short-term 51Cr release assay in vitro.

• OSTI ID: 5584198
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 31:2; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

550300 -- Cytology
551000* -- Physiological Systems
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
IMMUNITY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
NEOPLASMS
ORGANS
RADIATIONS
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
SPLEEN
TIME DEPENDENCE
TUMOR CELLS
ULTRAVIOLET RADIATION
VERTEBRATES