Further characterization of immunological unresponsiveness induced in mice by ultraviolet radiation. II. Studies on the origin and activity of ultraviolet-induced suppressor lymphocytes

Journal Article · Sun Feb 01 04:00:00 EST 1981 · Transplantation; (United States)

OSTI ID:6564758

Thorn, R M; Fisher, M S; Kripke, M L

We are studying the development and mode of action of suppressor T cells induced by ultraviolet (UV) radiation, which prevent the rejection of syngeneic UV-induced tumors. Suppressor cells were induced in C3H mice by exposure to FS40 sunlamps for 1 hr, three times per week for 3 months. Neither thymectomy nor splenectomy prior to UV irradiation prevented the development of these suppressor T cells in other lymphoid tissues. When UV T cells were mixed with syngeneic UV-induced tumor cells they did not increase the incidence or growth rate of the tumors relative to tumor cells alone, suggesting that the suppressor cells function by interacting with normal lymphocytes and not by directly stimulating tumor growth. Although the suppressor cells were effective in vivo when injected i.v. or when injected locally with normal lymphocytes, they did not suppress cytotoxic effector lymphocytes in a short-term /sup 51/Cr release assay in vitro.

• Research Organization: National Cancer Inst. Frederick Cancer Research Center, MD
• OSTI ID: 6564758
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 31:2; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
IMMUNITY
IMMUNOSUPPRESSION
INTERMEDIATE MASS NUCLEI
ISOTOPES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MEDICINE
MICE
NEOPLASMS
NUCLEI
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SOMATIC CELLS
SPLENECTOMY
SURGERY
THYMECTOMY
TUMOR CELLS
ULTRAVIOLET RADIATION
VERTEBRATES