Further characterization of immunological unresponsiveness induced in mice by ultraviolet radiation

Journal Article · Sat Sep 01 04:00:00 EDT 1979 · Transplantation; (United States)

OSTI ID:5332380

Kripke, M L; Thorn, R M; Lill, P H; Civin, C I; Pazmino, N H; Fisher, M S

Ultraviolet (uv)-irradiated mice were compared with unirradiated mice for their susceptibility to primary and transplanted tumors etiologically unrelated to uv radiation. Although uv-irradiated mice are unable to reject transplants of highly antigenic syngeneic tumors induced by uv light, the growth of syngeneic, non-uv-induced tumors generally was not accelerated in these animals. Furthermore, uv-irradiated mice were no more susceptible to the induction of primary leukemias, mammary tumors, or sarcomas than were unirradiated animals. Tests of immune responses to weak transplantation antigens showed that uv-irradiated mice rejected H-Y-incompatible skin grafts as vigorously as did normal animals, and that the primary in vitro cytotoxic responses of spleen cells from uv-irradiated mice to trinitrophenyl (TNP)-modified syngeneic cells and to Hh antigens were unaffected. We conclude that the susceptibility of uv-irradiated mice to challenge with uv-induced tumors represents a selective unresponsiveness, and that it is not attributable to a generalized deficiency in the immune response to tumor-specific antigens or to weak transplantation antigens.

• Research Organization: National Cancer Inst., Frederick, MD
• OSTI ID: 5332380
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 28:3; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
551000 -- Physiological Systems
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGEN-ANTIBODY REACTIONS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CHEMICAL EXPLOSIVES
DISEASES
ELECTROMAGNETIC RADIATION
EXPLOSIVES
GLANDS
GRAFT-HOST REACTION
HEMIC DISEASES
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IMMUNITY
LEUKEMIA
MAMMALS
MAMMARY GLANDS
MICE
NEOPLASMS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
PICRIC ACID
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SARCOMAS
SPLEEN
TRANSPLANTS
TUMOR CELLS
ULTRAVIOLET RADIATION
VERTEBRATES