Modification of immunological potential by ultraviolet radiation. I. Immune status of short-term uv-irradiated mice. [Mice]

Journal Article · Mon Aug 01 04:00:00 EDT 1977 · Transplantation; (United States)

OSTI ID:7218560

Spellman, C W; Woodward, J G; Daynes, R A

C3Hf/HeN mice support the progressive growth of most transplanted syngeneic ultraviolet (uv) light-induced tumors following short-term uv exposure whereas nonexposed mice reject these tumors. Because an immunosuppressive role in uv-mediated tumor susceptibility might be suggested by these observations, a comparison of several immunological parameters has been conducted. These include antibody production, proliferation in response to antigenic and mitogenic stimulation, and the generation of cytotoxic effector cells by normal or short-term uv-exposed mice. The results indicate that short-term uv irradiation of mice does not result in any readily detectable alterations of the host's immune system other than the consistent loss of the antitumor response mediating rejection of the transplanted uv-induced tumor.

• Research Organization: Univ. of Utah, Salt Lake City
• OSTI ID: 7218560
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 24:2; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL PROLIFERATION
DISEASES
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
IMMUNOSUPPRESSION
MAMMALS
MICE
NEOPLASMS
RADIATION EFFECTS
RADIATIONS
RODENTS
TRANSPLANTS
ULTRAVIOLET RADIATION
VERTEBRATES