Immunologic parameters of ultraviolet carcinogenesis. [Mice]

Journal Article · Thu Jul 01 04:00:00 EDT 1976 · J. Natl. Cancer Inst.; (United States)

OSTI ID:7343029

Kripke, M L ^[1]; Fisher, M S

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1. Frederick Cancer Research Center, MD

Skin tumors induced in mice by uv light are usually immunologically rejected by normal syngeneic recipients. We evaluated, the immune status of primary hosts against these highly antigenic tumors immediately after surgical removal of the primary tumor. All primary hosts were susceptible to challenge with their autochthonous tumors, though most of these were rejected by untreated control mice. Primary hosts were also susceptible to challenge with isografts of antigenically dissimilar uv-induced neoplasms. The susceptibility of the primary hosts to tumor challenge was probably induced by chronic exposure to uv light, since uv-irradiated non-tumor-bearing mice were also susceptible to challenge with these tumors. Although uv-treated mice were unable to reject these syngeneic tumors, they could reject skin and tumor allografts. Further, uv irradiation did not interfere with the second-set rejection of syngeneic uv-induced tumors in mice that were specifically immunized before uv treatment.

• OSTI ID: 7343029
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 57:1; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
MAMMALS
MICE
NEOPLASMS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SKIN
TRANSPLANTS
ULTRAVIOLET RADIATION
VERTEBRATES