Studies into the transplantation biology of ultraviolet light-induced tumors. [Mice]

Journal Article · Fri Apr 01 04:00:00 EST 1977 · Transplantation; (United States)

OSTI ID:7110126

Daynes, R A; Spellman, C W; Woodward, J G; Stewart, D A

The majority of skin tumors induced in mice by ultraviolet (uv) light are rejected when implanted into normal syngeneic recipients. Subcarcinogenic levels of uv light exposure render the normally resistant mice susceptible to tumor challenge. The immunoregulatory effect of uv light appears to be additive, since the growth rate of a tumor transplant is dependent upon the length of uv exposure administered prior to implantation. This suppressive influence does not appear to be directly mediated by the uv light, because the amputation of uv-irradiated tail skin allows for a retention of tumor resistance in otherwise tumor-susceptible hosts. uv-irradiated mice could also be immunized against uv tumors, which suggests that immune recognition of tumor-specific transplantation antigens has not been inhibited. The ability of uv exposure to alter normal immunological reactivity to uv-induced tumors is possibly an integral factor in the mechanism underlying uv carcinogenesis.

• Research Organization: Univ. of Utah, Salt Lake City
• OSTI ID: 7110126
• Journal Information: Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 23:4; ISSN TRPLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DISEASES
ELECTROMAGNETIC RADIATION
IMMUNE REACTIONS
MAMMALS
MICE
NEOPLASMS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
SKIN
TRANSPLANTS
ULTRAVIOLET RADIATION
VERTEBRATES