Suppression of antigraft immunity by preimmunization. II. Characterization of the suppressor cells
Journal Article
·
· Transplantation; (United States)
OSTI ID:6305794
Immunization of mice with irradiated (20 Gy) or non-irradiated allogeneic spleen cells i.v. induces delayed-type hypersensitivity (DTH)-reactive T cells, as well as suppressor T cells, against histocompatibility antigens. The suppressor T cells are unable to suppress the induction and functional activity of the simultaneously activated DTH-reactive T cells. However, the suppressor T cells do suppress the generation of DTH-reactive T cells after subsequent s.c. immunization of the same mice, and after transfer into secondary recipients. Systemic transfer of suppressor T cells is effective the first few days after their induction, and affects the afferent limb of the DTH response. The population of suppressor T cells, which is essential for the systemic transfer of suppression, appeared to be Lyt-1+2+. Splenectomy experiments showed that the spleen is not essential for induction of the suppressor T cells. The precursors of the suppressor T cells belong to the pool of recirculating T lymphocytes; they are insensitive to adult thymectomy and can be depleted by antithymocyte serum treatment.
- Research Organization:
- Erasmus Univ., Rotterdam, Netherland
- OSTI ID:
- 6305794
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 37:5; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Regulation of delayed-type hypersensitivity: VI. Antigen-specific suppressor T cells and suppressor factor for delayed-type hypersensitivity to histocompatibility antigens
Abrogation of the capacity of delayed-type hypersensitivity responses to alloantigens by intravenous injection of neuraminidase-treated allogeneic cells
Immunity to herpes simplex virus type 2. Suppression of virus-induced immune responses in ultraviolet B-irradiated mice
Journal Article
·
Thu Dec 31 23:00:00 EST 1981
· Transplantation; (United States)
·
OSTI ID:6715928
Abrogation of the capacity of delayed-type hypersensitivity responses to alloantigens by intravenous injection of neuraminidase-treated allogeneic cells
Journal Article
·
Mon Nov 30 23:00:00 EST 1987
· J. Immunol.; (United States)
·
OSTI ID:5350022
Immunity to herpes simplex virus type 2. Suppression of virus-induced immune responses in ultraviolet B-irradiated mice
Journal Article
·
Thu Oct 15 00:00:00 EDT 1987
· J. Immunol.; (United States)
·
OSTI ID:5715086
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
IMMUNOLOGY
IMMUNOSUPPRESSION
INJECTION
INTAKE
INTRAVENOUS INJECTION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEDICINE
RADIATION EFFECTS
SOMATIC CELLS
SPLEEN CELLS
SPLENECTOMY
SUBCUTANEOUS INJECTION
SURGERY
TRANSPLANTS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
IMMUNOLOGY
IMMUNOSUPPRESSION
INJECTION
INTAKE
INTRAVENOUS INJECTION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEDICINE
RADIATION EFFECTS
SOMATIC CELLS
SPLEEN CELLS
SPLENECTOMY
SUBCUTANEOUS INJECTION
SURGERY
TRANSPLANTS