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Immunity to herpes simplex virus type 2. Suppression of virus-induced immune responses in ultraviolet B-irradiated mice

Journal Article · · J. Immunol.; (United States)
OSTI ID:5715086
; ;
Ultraviolet B irradiation (280 to 320 nm) of mice at the site of intradermal infection with herpes simplex virus type 2 increased the severity of the herpes simplex virus type 2 disease and decreased delayed-type hypersensitivity (DTH) responses to viral antigen. Decrease in DTH resulted from the induction of suppressor T cells, as evidenced by the ability of spleen cells from UV-irradiated mice to inhibit DTH and proliferative responses after adoptive transfer. Lymph node cells from UV-irradiated animals did not transfer suppression. DTH was suppressed at the induction but not the expression phase. Suppressor T cells were Lyt-1+, L3T4+, and their activity was antigen-specific. However, after in vitro culture of spleen cells from UV-irradiated mice with herpes simplex virus type 2 antigen, suppressor activity was mediated by Lyt-2+ cells. Culture supernatants contained soluble nonantigen-specific suppressive factors.
Research Organization:
Univ. of Maryland School of Medicine, Baltimore
OSTI ID:
5715086
Journal Information:
J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 139:8; ISSN JOIMA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIGENS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
HERPES SIMPLEX
IMMUNITY
IMMUNOSUPPRESSION
INFECTIOUS DISEASES
INHIBITION
LEUKOCYTES
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANS
RADIATIONS
RODENTS
SENSITIVITY
SKIN
SKIN DISEASES
SOMATIC CELLS
SPECIFICITY
SPLEEN CELLS
ULTRAVIOLET RADIATION
VERTEBRATES
VIRAL DISEASES