Ultraviolet-irradiated urocanic acid suppresses delayed-type hypersensitivity to herpes simplex virus in mice

Journal Article · Sat Nov 01 04:00:00 EST 1986 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12456257· OSTI ID:7133120

Ross, J A; Howie, S E; Norval, M; Maingay, J; Simpson, T J

Ultraviolet radiation is known to induce a transient defect in epidermal antigen presentation which leads to the generation of antigen-specific suppression of the delayed-type hypersensitivity (DTH) response. The putative receptor in skin for the primary event in UV-suppression is urocanic acid (UCA) which may then interact locally, or systemically, with antigen presenting cells or initiate a cascade of events resulting in suppression. We present the first direct evidence that UCA, when irradiated with a dose (96 mJ/cm2) of UVB radiation known to suppress the DTH response to herpes simplex virus, type 1 (HSV-1) in mice, can induce suppression following epidermal application or s.c. injection of the irradiated substance. This suppression is transferable with nylon wool-passed spleen cells.

• Research Organization: Univ. of Edinburgh Medical School, Scotland
• OSTI ID: 7133120
• Journal Information: J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 5; ISSN JIDEA
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
ANTIGENS
AZOLES
BODY
CARBOXYLIC ACIDS
DISEASES
ELECTROMAGNETIC RADIATION
EPIDERMIS
EPITHELIUM
HERPES SIMPLEX
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMMUNE REACTIONS
INFECTIOUS DISEASES
INFECTIVITY
MAMMALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATIONS
RODENTS
SENSITIVITY
SKIN
SKIN DISEASES
SPLEEN
TISSUES
ULTRAVIOLET RADIATION
UROCANIC ACID
VERTEBRATES
VIRAL DISEASES