Induction of suppression of delayed type hypersensitivity to herpes simplex virus by epidermal cells exposed to UV-irradiated urocanic acid in vivo

Journal Article · Wed Dec 31 23:00:00 EST 1986 · Viral Immunology; (USA)

DOI:https://doi.org/10.1089/vim.1987.1.191· OSTI ID:5348771

Ross, J A; Howie, S E; Norval, M; Maingay, J P ^[1]

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1. Western General Hospital, Edinburgh (Scotland)

Urocanic acid (UCA), the putative photoreceptor for ultraviolet radiation (UV)-induced suppression, undergoes a UV-dependent trans to cis isomerisation. Epidermal cells from mice painted with UCA, containing a known proportion of the cis-isomer, generate suppression of the delayed type hypersensitivity response to herpes simplex virus type 1 (HSV-1) when transferred to naive syngeneic recipients at the same time and site as infection with HSV-1. One T suppressor cell subset, of phenotype (Thy1+, L3T4+, Ly2-), is induced by the cis-UCA modified epidermal cell transfer. Flow cytometric analysis of the epidermal cells from skin treated with UV or cis-UCA indicates an overall reduction from normal in the number of cells expressing MHC Class II antigens, but no alteration in the number expressing I-J antigens.

• OSTI ID: 5348771
• Journal Information: Viral Immunology; (USA), Journal Name: Viral Immunology; (USA) Vol. 1:3; ISSN VIIME; ISSN 0882-8245
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CELL FLOW SYSTEMS
CHEMICAL REACTIONS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
EPIDERMIS
EPITHELIUM
HERPES SIMPLEX
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMMUNOSUPPRESSION
INFECTIOUS DISEASES
ISOMERIZATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATIONS
RADIOINDUCTION
RODENTS
SKIN
SKIN DISEASES
SOMATIC CELLS
TISSUES
ULTRAVIOLET RADIATION
UROCANIC ACID
VERTEBRATES
VIRAL DISEASES