Radioprotective properties of hypoxia after administration of antihypoxic agents. [Mice, rats, dogs, gamma radiation]

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:7300323

Titov, B A; Zherebchenko, P G; Znamenskii, V V; Terekhov, A V

In experiments on mice, rats and dogs, it has been shown that antihypoxic agents--gutimin (guanylthiourea) and vitamin B/sub 15/--given separately or in combination do not lower the radioprotective effect of hypoxia, according to the postradiation survival test. However, separate or combined administration of gutimin and vitamin B/sub 15/ lowers the radioprotective efficacy of hypoxia in mice, according to the criterion of number of bone marrow karyocytes. The possible mechanisms of this inconsistency in action of antihypoxic agents are discussed.

• OSTI ID: 7300323
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:1; ISSN RADBA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANOXIA
ANTITHYROID DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBONIC ACID DERIVATIVES
DOGS
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
IONIZING RADIATIONS
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATION PROTECTION
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SURVIVAL TIME
THIOUREA
THIOUREAS
VERTEBRATES
VITAMIN B GROUP
VITAMINS