Radioprotective properties of hypoxia after administration of antihypoxic agents. [Mice, rats, dogs, gamma radiation]

Journal Article · Sat Jan 01 00:00:00 EST 1977 · Radiobiology (USSR) (Engl. Transl.); (United States)

OSTI ID:7300323

Titov, B A; Zherebchenko, P G; Znamenskii, V V; Terekhov, A V

In experiments on mice, rats and dogs, it has been shown that antihypoxic agents--gutimin (guanylthiourea) and vitamin B/sub 15/--given separately or in combination do not lower the radioprotective effect of hypoxia, according to the postradiation survival test. However, separate or combined administration of gutimin and vitamin B/sub 15/ lowers the radioprotective efficacy of hypoxia in mice, according to the criterion of number of bone marrow karyocytes. The possible mechanisms of this inconsistency in action of antihypoxic agents are discussed.

• OSTI ID: 7300323
• Journal Information: Radiobiology (USSR) (Engl. Transl.); (United States), Vol. 17:1; Other Information: Translated from Radiobiologiya; 17: No. 1, 63-66(1977)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOXIA
RADIOSENSITIVITY EFFECTS
ORGANIC SULFUR COMPOUNDS
SURVIVAL TIME
BIOLOGICAL RADIATION EFFECTS
THIOUREA
VITAMIN B GROUP
DOGS
GAMMA RADIATION
MICE
RADIATION PROTECTION
RATS
ANIMALS
ANTITHYROID DRUGS
BIOLOGICAL EFFECTS
CARBONIC ACID DERIVATIVES
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
THIOUREAS
VERTEBRATES
VITAMINS
560152* - Radiation Effects on Animals- Animals