Induction of marrow hypoxia by radioprotective agents
Technical Report
·
OSTI ID:7018562
Many compounds that possess sulfhydryl groups have been shown to protect bone marrow from radiation injury. The most effective thiol radioprotective agent is ethiofos (S-2-(3-aminopropylamino)ethylphosphorothoic acid or WR-2721). The ability of thiol and non-thiol radioprotectors to induce hypoxia was determined using binding of ({sup 3}H)misonidazole by bone marrow cells as a measure of hypoxia. When administered at maximally radioprotective doses, four drugs (WR-2721, cysteamine, 5-hydroxytryptamine, and 16,16-dimethyl prostaglandin E2) significantly increased the amount of ({sup 3}H)misonidazole bound by marrow cells, while no significant increase in binding was observed with three other agents (endotoxin, AET, superoxide dimutase). Doses of WR-2721 previously shown to provide suboptimal radioprotection did not significantly increase {sup 3}H-misonidazole binding. These results suggest that the physiological effects of some radioprotectors, that is, their ability to induce marrow hypoxia, may contribute to their efficacy in vivo.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 7018562
- Report Number(s):
- AD-A-214330/3/XAB; AFRRI-SR--89-26
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANOXIA
ANTIGENS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
BONE MARROW CELLS
CHEMICAL BONDS
CONNECTIVE TISSUE CELLS
DRUGS
ENDOTOXINS
EVALUATION
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IMIDAZOLES
IN VIVO
INJURIES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MATERIALS
MISONIDAZOLE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIZERS
SOMATIC CELLS
THIOLS
TISSUES
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
TRITIUM
YEARS LIVING RADIOISOTOPES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANOXIA
ANTIGENS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
BONE MARROW CELLS
CHEMICAL BONDS
CONNECTIVE TISSUE CELLS
DRUGS
ENDOTOXINS
EVALUATION
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN ISOTOPES
IMIDAZOLES
IN VIVO
INJURIES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MATERIALS
MISONIDAZOLE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIZERS
SOMATIC CELLS
THIOLS
TISSUES
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
TRITIUM
YEARS LIVING RADIOISOTOPES