Induction of marrow hypoxia by radioprotective agents

Journal Article · Thu Jun 01 04:00:00 EDT 1989 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577415· OSTI ID:5716375

Allalunis-Turner, M J; Walden, Jr, T L; Sawich, C

The ability of thiol and non-thiol radioprotectors to induce hypoxia was determined using the binding of (/sup 3/H)misonidazole by bone marrow cells as a measure of hypoxia. When administered at maximally radioprotective doses, four drugs (WR-2721, cysteamine, 5-hydroxytryptamine, and 16,16-dimethyl prostaglandin E2) significantly increased the amount of (/sup 3/H)misonidazole bound by marrow cells, while no significant increase in binding was observed with three other agents (endotoxin, AET, superoxide dimutase). Doses of WR-2721 previously shown to provide suboptimal radioprotection did not significantly increase /sup 3/H-misonidazole binding. These results suggest that the physiological effects of some radioprotectors, that is, their ability to induce marrow hypoxia, may contribute to their efficacy in vivo.

• Research Organization: Cross Cancer Institute, Edmonton, Alberta (Canada)
• OSTI ID: 5716375
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 118:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AET
AMINES
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIGENS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BONE MARROW CELLS
CARBONIC ACID DERIVATIVES
CONNECTIVE TISSUE CELLS
DRUGS
ELEMENTS
ENDOTOXINS
ENZYMES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
MEA
MICE
NEUROREGULATORS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDOREDUCTASES
OXYGEN
PROSTAGLANDINS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RODENTS
SEROTONIN
SOMATIC CELLS
SUPEROXIDE DISMUTASE
SYMPATHOMIMETICS
THIOLS
THIOUREAS
TOXIC MATERIALS
TOXINS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TRYPTAMINES
VERTEBRATES